.Nature Medicine, Posted online: thirteen September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized period 3b/4 DESTINY-Breast12 research, trastuzumab deruxtecan (T-DXd) procedure of individuals along with HER2+ state-of-the-art bosom cancer as well as active or steady mind metastases presented constant intracranial activity and also wide spread effectiveness of T-DXd.